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KMID : 1140120090140020118
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Cancer Prevention Research
2009 Volume.14 No. 2 p.118 ~ p.123
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Inhibitory Effects of Morachalcone A on Lipopolysaccharide - Induced Nitric Oxide Production in Raw 264.7 Cells
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Kang You-Jin
Han Ar-Reum
Lee Sang-Kook
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Abstract
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Overproduced nitric oxide (NO) by inducible nitric oxide synthase (iNOS) causes tissue damage, chronic inflammation, and carcinogenesis. In this view, the potential iNOS inhibitors have been considered as anti-inflammatory or cancer chemopreventive agents. In this study, we investigated the potential capacities of morachalcone A isolated from the heartwood of Artocarpus communis as anti-inflammatory or cancer chemopreventive agent. Morachalcone A exhibited inhibitory activities against lipopolysaccharide-induced nitric oxide production in cultured RAW 264.7 cells. Using western blot and reverse transcriptase-polymerase chain reaction analysis, morachalcone A showed the suppression of iNOS protein and mRNA expression in a dose-dependent manner. These findings suggested that morachalcone A might be a potential lead candidate for anti-inflammatory or cancer chemopreventive agent.
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KEYWORD
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Morachalcone A, Raw 264.7 cells, iNOS, IκB-α
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